Panos Papadiamantis: Cardio Metabolic Analysis and Effective Training

“In order to prescribe an effective workout plan. You need to understand that each type of training is going to have a different adaptation on your body.
We do strength training in order to ramp up our metabolism.
We do cardio training in order to enhance our cellular health and fat burning efficiency.
We do hit training in order to improve our cardiovascular and pulmonary fitness.
So three different systems, three different types of workouts as I like to say, in our programming, we don’t try to fix everything all at once.”

— PANOS PAPADIAMANTIS

Panos Papadiamantis, Co-Founder of PNOE, the world’s first portable cardio-metabolic analyzer. What that is, it’s a mask that you wear during a 10-minute test on a treadmill, and from that, you gain incredible insights into your health and fitness.

PNOĒ is on a quest to bring cardio-metabolic analysis to everyone. As the gold standard for nutrition & exercise prescription, the most non-invasive method for cardiovascular disease screening, the clinical standard for triaging between pulmonary and cardiac limitations as well as a valuable tool in detecting latent causes of myoskeletal problems, cardio-metabolic analysis is rapidly becoming the central assessment in holistic health.

Explore PNOE here!


Show Notes:

[00:04:20] What is PNOE?

Metabolism

How Does Oxygen Get to Muscles?

[00:10:10] One of the biggest misconceptions of metabolic testing

VO2 Max - Definition

“What you're describing now is probably one of the biggest misconceptions about metabolic testing that metabolic testing is basically viewed as VO2 max testing. VO2 max is simply the highest number of one of the variables recorded during the test. There are so many other things that are scanned during a metabolic test.

You scan your cardiovascular fitness, your respiratory fitness, you are metabolic efficiency, which is how fast or slow your metabolism is. In other words, whether you're burning fewer or more calories than the average person of your size and gender. You can see to what extent your breathing is affecting your posture.

You can see to what extent your breathing is affecting your cognition. You can screen how effective you are in burning fat. It's actually the gold standard for assessing fat-burning efficiency, which is highly correlated with cellular health. There are so many, many things that are scattered throughout metabolic tests, but you know, because of how difficult devices were to operate until today, and because of a very small extent that they supported the user. When it comes to analyzing data, most of that information was largely unexploited until today.“

[00:12:31] Describing the technology

[00:15:47] Studies that validate PNOE?

Validity and Reliability of the New Portable Metabolic Analyzer PNOE

[00:16:51] Calorie Deviation

Whoop Podcast: Panos Papadiamantis, Co-Founder of PNOE

[00:18:02] What is Panos' Background?

“Then at some point, we were like, okay, maybe we should, you know, try and turn this thing into a company. There is an obviously great market potential if you're able to measure a person's metabolism. To be very honest with you when we first started, the only thing that we knew about metabolism was that it was a big buzzword in the fitness industry.

Nothing more than that. If you told me back then about the potential of metabolic testing to screen for hyperventilation and how hyperventilation affects your posture, I wouldn't know anything about that. Anyways, it was sort of a gut feeling. We were like, Hey, you know, metabolism is something so central in human physiology.

If you build a device that actually measures it, there's gotta be a way to grow a good business out of that. And this is how it started. 

And, you know, by the way, this is advice to anyone who's starting a company to not start a company based on that mentality. 

This is what Silicon Valley investors define as technology looking for a need. And we were lucky. We were lucky in the sense that we actually found the need for a product-market fit. But, you know, it might have very well been the case that we wouldn't have found anything. So, usually the right way to start things is, Hey, I see that people want to do VO2 max testing more easily. And this is why I want to build a field to a max testing device, et cetera. We did it the other way around. And as a result, you know, we have many near-death experiences, which are very constructive. 

And in some ways, I think part of the reason why as a company, we are so scientific and, and we provide a lot of education to our users as well as because we needed to educate ourselves extensively in order to understand where our device will ultimately be used.

So this is kind of a this is kind of some, some background information on how everything started.”

Product/Market Fit

[00:23:20] Accessibility of the technology and what understanding your metabolism can provide for average users

[00:27:01] Understanding metabolic efficiency

Cellular respiration

Obesity and metabolic efficiency

[00:29:26] Uses for different types of training

“In order to prescribe an effective workout plan. You need to understand that each type of training is going to have a different adaptation on your body.

We do strength training in order to ramp up our metabolism.

We do cardio training in order to enhance our cellular health and fat burning efficiency.

We do hit training in order to improve our cardiovascular and pulmonary fitness.

So three different systems, three different types of workouts as I like to say, in our programming, we don’t try to fix everything all at once.”

[00:32:27] Mitochondria and metabolism

Mitochondria 

Nicotinamide adenine dinucleotide (NAD)

Resveratrol

[00:37:19] Frequency of testing?

[00:38:18] Bad advice in training

[00:41:01] Entry level recommendation for movement 

“Strength training. What I like to say is that it starts under the squat rack. This is, this is where you build muscle. This is where you build your body. And, you know, especially when it comes to longevity and keeping weight off and being able to live off a high-quality life, you need to have muscle on your body.

That's the most important thing. Obviously, you should be working on your audio, and you should make sure that you have a high VO2 peak. You know, if anything, we are the biggest proponents of the VO2 peak as a health metric. It is well established as the most, foundational health metric and the greatest indicator for overall health, etc. But make sure that, you know, you keep weight off and you are able to perform physical work without risk of getting injured, et cetera. The most important thing is me building a strong myoskeletal system, and this is done as I like to say, it starts under the squat rack. So, obviously it's more complicated in that this is what I like to say just to describe to give a very broad overview of how this program would look like in the beginning. Obviously, as I said, it's going to have cardio, training, hit training, et cetera, down the road, but it starts by building a strong myoskeletal foundation.”

[00:43:21] What to do when feeling overwhelmed or unfocused?

[00:44:21] Any routines that help Panos?

[00:46:09] Advice the young or driven?

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